| Original | Jpn J Radiol Technol 2006; 62 (9) : |
| Utility of Axial Images in an Early Alzheimer Disease Diagnosis Support System (VSRAD) | |
| Masami Goto, Shigeki Aoki,1) Osamu Abe,1) Tomohiko Masumoto, Yasushi Watanabe, Yoshiroh Satake, Katsuji Nishida, Kenji Ino, Keiichi Yano, Kyohhito Iida, Kazuo Mima, and Kuni Ohtomo1) |
| Department of Radiological Technology, University of Tokyo Hospital 1) Department of Radiology, University of Tokyo Hospital |
| Received May 9, 2006; Revision accepted July 10, 2006; Code No. 261 |
| Summary |
| In recent years, voxel-based morphometry (VBM) has become a popular tool for the early diagnosis of Alzheimer disease. The Voxel-Based Specific Regional Analysis System for Alzheimer's Disease (VSRAD), a VBM system that uses MRI, has been reported to be clinically useful. The able-bodied person database (DB) of VSRAD, which employs sagittal plane imaging, is not suitable for analysis by axial plane imaging. However, axial plane imaging is useful for avoiding motion artifacts from the eyeball. Therefore, we created an able-bodied person DB by axial plane imaging and examined its utility. We also analyzed groups of able-bodied persons and persons with dementia by axial plane imaging and reviewed the validity. After using the DB of axial plane imaging, the Z-score of the intrahippocampal region improved by 8 in 13 instances. In all brains, the Z-score improved by 13 in all instances. |
| Key words: | Alzheimer disease (AD), voxel-based morphometry (VBM), VSRAD, Z-score, sensitivity revision |
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